The effects of thermal insult on living tissue have been studied by direct microscopic observation of the circulatory system’s response to a controlled trauma regimen. An experimental apparatus has been developed which utilizes a unique high and low temperature stage in conjunction with a precision thermal control system to examine the injury process in the microcirculation of the golden hamster cheek pouch. Unique features of this experimental apparatus are: (1) continuous monitoring of the injury processes at the cellular level, (2) capability for quantitative assay of thermal injury, (3) precise control over the thermal parameters that govern injury, (4) versatility in isolating the effects of these individual parameters. The important thermal parameters monitored using this experimental procedure are the time rates of change of temperature during burning and cooling, the maximum temperature reached, and the length of time the tissue was held at this temperature. With this type of experimental apparatus any portion of the burn protocol, such as the maximum temperature reached during burning, may be varied while holding all other parameters constant. It is well documented that the microvascular bed is a primary site for manifestation of burn wound injury. Burn injury occurs as a consequence of rate dependent physiochemical processes, and, therefore, develops over a finite period of time subsequent to trauma. The experimental technique is designed to determine the gross response of the microvascular system to burn trauma. Initial investigations on burn injury have demonstrated a direct dependency of the extent of damage upon both the maximum temperature attained and the duration of exposure. The minimum temperature required to produce stasis within 20 s after completion of the burn in 95 ±5 percent of the microcirculation decreased exponentially with burn duration between the extremes of 85°C for 1 s exposure and 60°C for 100 s exposure.
Skip Nav Destination
Article navigation
Research Papers
An Experimental Investigation of Burn Injury in Living Tissue
D. C. Ross,
D. C. Ross
Bio-Medical Engineering Program, The University of Texas at Austin, Austin, Texas
Search for other works by this author on:
K. R. Diller
K. R. Diller
Bio-Medical Engineering Program, The University of Texas at Austin, Austin, Texas
Search for other works by this author on:
D. C. Ross
Bio-Medical Engineering Program, The University of Texas at Austin, Austin, Texas
K. R. Diller
Bio-Medical Engineering Program, The University of Texas at Austin, Austin, Texas
J. Heat Transfer. May 1976, 98(2): 292-296 (5 pages)
Published Online: May 1, 1976
Article history
Received:
February 3, 1976
Online:
August 11, 2010
Citation
Ross, D. C., and Diller, K. R. (May 1, 1976). "An Experimental Investigation of Burn Injury in Living Tissue." ASME. J. Heat Transfer. May 1976; 98(2): 292–296. https://doi.org/10.1115/1.3450533
Download citation file:
Get Email Alerts
Cited By
The Effect of Biot Number on a Generalized Heat Conduction Solution
J. Heat Mass Transfer
Numerical Investigation of Conjugate Natural Convection From a Vertical Cylindrical Open Cavity
J. Heat Mass Transfer (August 2023)
Heat Transfer and Pressure Loss of Turbulent Flow in a Wedge-Shaped Cooling Channel With Different Types of Triply Periodic Minimal Surfaces
J. Heat Mass Transfer (September 2023)
Related Articles
Thermal Therapy in Urologic Systems: A Comparison of Arrhenius and Thermal Isoeffective Dose Models in Predicting Hyperthermic Injury
J Biomech Eng (July,2009)
Endometrial Thermal Balloon Ablation Using a High Temperature, Pulsed System: A Mathematical Model
J Biomech Eng (December,2003)
Continuum thermomechanics and the clinical treatment of disease and injury
Appl. Mech. Rev (March,2003)
Correlation of HSP70 Expression and Cell Viability Following Thermal Stimulation of Bovine Aortic Endothelial Cells
J Biomech Eng (October,2005)
Related Proceedings Papers
Related Chapters
The Impact of Plant Economics on the Design of Industrial Energy Systems
Industrial Energy Systems
Recovery from a Catastrophic Station Blackout (PSAM-0458)
Proceedings of the Eighth International Conference on Probabilistic Safety Assessment & Management (PSAM)
Introduction
Mechanical Blood Trauma in Circulatory-Assist Devices