This review summarizes computer simulation methodologies of air-particle flow, results of drug-aerosol transport/deposition in models of the human respiratory system, as well as aspects of drug-aerosol targeting and associated inhalation devices. After a brief introduction to drug delivery systems in general, the required modeling and simulation steps for optimal drug-aerosol delivery in the lung are outlined. Starting with medical imaging and file conversion of patient-specific lung-airway morphologies, the air-particle transport phenomena are numerically solved for a representative inhalation flow rate of . Focusing on microspheres and droplets, the complex airflow and particle dynamics, as well as the droplet heat and mass transfer are illustrated. With this foundation as the background, an overview of present inhaler devices is presented, followed by a discussion of the methodology and features of a new smart inhaler system (SIS). With the SIS, inhaled drug-aerosols can be directly delivered to any predetermined target area in the human lung.
Skip Nav Destination
e-mail: ck@eos.ncsu.edu
Article navigation
Research Papers
Optimal Drug-Aerosol Delivery to Predetermined Lung Sites
Clement Kleinstreuer,
Clement Kleinstreuer
Department of Mechanical and Aerospace Engineering and Department of Biomedical Engineering,
e-mail: ck@eos.ncsu.edu
North Carolina State University
, Raleigh, NC 27695; University of North Carolina
, Chapel Hill, NC 27599
Search for other works by this author on:
Zhe Zhang
Zhe Zhang
Department of Mechanical and Aerospace Engineering,
North Carolina State University
, Raleigh, NC 27695
Search for other works by this author on:
Clement Kleinstreuer
Department of Mechanical and Aerospace Engineering and Department of Biomedical Engineering,
North Carolina State University
, Raleigh, NC 27695; University of North Carolina
, Chapel Hill, NC 27599e-mail: ck@eos.ncsu.edu
Zhe Zhang
Department of Mechanical and Aerospace Engineering,
North Carolina State University
, Raleigh, NC 27695J. Heat Transfer. Jan 2011, 133(1): 011002 (12 pages)
Published Online: September 27, 2010
Article history
Received:
March 31, 2010
Revised:
April 28, 2010
Online:
September 27, 2010
Published:
September 27, 2010
Citation
Kleinstreuer, C., and Zhang, Z. (September 27, 2010). "Optimal Drug-Aerosol Delivery to Predetermined Lung Sites." ASME. J. Heat Transfer. January 2011; 133(1): 011002. https://doi.org/10.1115/1.4002224
Download citation file:
Get Email Alerts
Cited By
Entropic Analysis of the Maximum Output Power of Thermoradiative Cells
J. Heat Mass Transfer
Molecular Dynamics Simulations in Nanoscale Heat Transfer: A Mini Review
J. Heat Mass Transfer
Related Articles
Targeted Drug Aeroso Deposition Analysis for a Four-Generation Lung Airway Model With Hemispherical Tumors
J Biomech Eng (April,2003)
Design of a Smart Inhaler System for Improved Aerosol Drug Delivery
J. Med. Devices (June,2008)
Improving Pulmonary Nanotherapeutics Using Helical Aerosol Streams: An In Silico Study
J Biomech Eng (November,2021)
Related Proceedings Papers
Related Chapters
Drug Delivery Nanosystems as a Promising Area of Modern Chemistry and Medicine. Silica Nanoparticles as Potential Drug Carriers
Silica Nanoparticles as Drug Delivery System for Immunomodulator GMDP (Biomedical & Nanomedical Technologies - Concise Monograph Series)
Chitosan-Based Drug Delivery Systems
Chitosan and Its Derivatives as Promising Drug Delivery Carriers
Conclusions
Chitosan and Its Derivatives as Promising Drug Delivery Carriers