A numerical simulation of structural vibration and acoustic radiation is presented for a finite, fluid-loaded plate reinforced with two sets of orthotropic stiffeners. The attempt is to achieve a physical understanding of the dynamic behaviour and especially the acoustic radiation of the stiffened plate under combined force and moment excitations. Finite element method (FEM) is employed for calculation of the in-vacuo normal modes of the stiffened plate. The coupled modes with a heavy fluid (water), vibration response and acoustic radiation of the plate under given force and/or moment excitation are calculated using boundary element method (BEM). Numerical simulation results are detailed to address the significance of moment in combined force-moment excitations and, more importantly, the cancelling of the combined excitation in both structural vibration response and the associated acoustic radiation into the surrounding fluid.