Modeling and dynamic analysis of a slider-crank mechanism with flexible joint and coupler is presented. The equations of motion of the mechanism model are formulated using a virtual work multibody formalism and cast in terms of a minimum set of generalized coordinates through a Jacobian matrix expansion. Numerical results show the influence of time-varying coefficients on the mechanism dynamic behavior due to a repeated task. The results illustrate that the joint motion and coupler deformation are highly coupled. The joint response is dominated by double frequency of input, however, the coupler deformation is influenced by the same frequency as that of excitation. Increase in joint stiffness tends to decrease the variations in coupler deformation.