In this study, two-dimensional (2D) numerical simulations of liquid slip flows in parallel-plate microchannels have been performed to obtain heat transfer characteristics and entropy generation rate under asymmetric heating conditions. Heat transfer analysis has been conducted along with second-law analysis through utilizing temperature-dependent thermophysical properties. The results indicate that temperature-dependent thermophysical properties have a positive effect on convective heat transfer and entropy generation. Nusselt numbers of the upper and lower plates and global entropy generation rates are significantly affected by slip parameter and heat flux ratio. It is shown that Nusselt number of the lower plate may have very large but finite values at a specific heat flux ratio. This finding resembles to analytical solutions, where singularities leading to an infinite Nusselt number exist.