Humidification–dehumidification (HDH) desalination is a simple technique to produce desalinated water from saline water. Dehumidifier is a key component in the HDH system, which influences the desalination yield. In the current work, a three-dimensional multiphase numerical simulation study is carried out on third dehumidifier alone to evaluate its performance using computational fluid dynamics (CFD) code. The simulation result is validated with experimental readings, and it is found that there exists a very close agreement between the predicted and the experimental readings. The key parameters influencing the dehumidifier performance are chilled water temperature, humid air temperature, and volume fraction. Experiments are carried out on the combined two stage HDH plant at different hot water temperature and flow rates. A detailed study of dehumidification process is carried out using ansys cfx 15.0 tool by solving the governing equations, namely, mass, momentum, and energy, with turbulence modeled through shear stress transport (SST) k–ω model of closure. Multiphase is solved using a free-surface multiphase model. The measured average cooled air temperature and relative humidity (RH) at the exit of third dehumidifier are 21 °C and 67%. The desalinated water produced at a hot water flow of 100 LPH is found as 2205 ml/h from the experiments. The CFD results are deviated by 0.41%, 6.45%, and −0.70% with that of experimental results at the dehumidifier for air temperature, velocity, and chilled water temperature, respectively.