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Review Articles

Recent Developments in Biotransport

[+] Author and Article Information
Liang Zhu

Department of Mechanical Engineering, University of Maryland Baltimore County, Baltimore, MD 21250zliang@umbc.edu

J. Thermal Sci. Eng. Appl 2(4), 040801 (Feb 24, 2011) (11 pages) doi:10.1115/1.4003511 History: Received November 24, 2010; Revised January 04, 2011; Published February 24, 2011; Online February 24, 2011

In the past ten years, one has seen rapid advancements in heat and mass transport applications in biology and medicine. The research activities have been shifted from fundamental development of better theoretical models accurately describing the thermal effect of local vasculature geometry and blood perfusion rate in the 1980s and 1990s to emphases on biotransport research with clear clinical applications and on how to utilize theoretical simulation and imaging techniques for better designing treatment protocols in those applications. This review will first describe briefly technical advancements in bioheat and mass transfer in the past several decades and then focus on two important applications in bioheat and mass transport covering different temperature ranges: hypothermia in brain injury and hyperthermia in tissue thermal damage. The contributions of nanotechnology, imaging tools, and multiscale modeling to the advancements will be discussed in the review.

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Copyright © 2010 by American Society of Mechanical Engineers
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Figures

Grahic Jump Location
Figure 1

Temperature elevations in a tumor with an irregular shape: (a) single injection and (b) multiple injections. Temperature elevations in the tumor are more uniform in (b).

Grahic Jump Location
Figure 2

Micro-CT images of nanoparticle deposition (bright color) in two tumors (dark color): (a) without heating and (b) after heating

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